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KMID : 0369820170470010001
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Jorunal of Korean Pharmaceutical Sciences
2017 Volume.47 No. 1 p.1 ~ p.10
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Multifunctional nano-sized fullerenes for advanced tumor therapy
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Youn Yu-Seok
Kwag Dong-Sup
Lee Eun-Seong
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Abstract
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There is an increasing demand for the development of functional photosensitizing nano-sized drugs. Fullerene, one of the new carbon molecules, has been considered to be a useful and versatile material for this purpose. Notably, fullerenes are water-insoluble, and they readily aggregate in aqueous solution. Therefore, fullerenes usually have been coupled with water-soluble, biocompatible, biodegradable polymers (e.g., polysaccharides, proteins, and other functional polymers), achieving their improved water-solubility and biocompatible properties. In particular, when fullerenes are paired with tumor-targeting ligands or stimuli-responsive polymers, these conjugates exhibit enhanced tumor recognition ability and improved tumor inhibition. Some groups encapsulated fullerenes into liposomes or nanoemulsions for various pharmaceutical purposes. This review provides an in-depth understanding of fullerene/polymer nanoparticles for effective fullerene-mediated tumor therapy.
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KEYWORD
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Fullerene, Polymer conjugate, Reactive oxygen species, Tumor therapy
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